CHEMOTHERAPY OF CHRONIC SINUSITIS, Especially by Continuous administration of large doses of Penicillin By R. OSAWA AND COLLEAGUES From the Department of Oto-rhino-laryngology, Tokyo Teishin Hospital Attached to the Ministry of Postal Service

The following is derived from joint works of the senior author and his colleagues; Drs. M. Hosui, T. Higuti, K. Akaike, R. otsuka, Y. Sakai and Y. Nakamura. There are many applicable methods in the treatment of chronic sinusitis with penicillin and there are some conflicting opinions about the results. In order to determine the degree of effectiveity and the limitation of penicillin therapy in chronic sinusitis, the authors carried out some studies in patients. 1. Basic Studies Ten cases, chosen at random, of chronic sinusitis had after admission into the hospital, their maxillary sinus exposed. After macroscopic and bacteriological studies, as well as excision of bioptic sections counter opening was created. Instead of being followed by a radical operation the exposed sinus was closed, penicillin instilled and the progress observed. 100,000 units of mix penicillin was used in from 5 to 6cc. of distilled water. From 25,000 to 50,000 units was given once every day. This proceduse was followed until no further improvement was observed by its use. The amount of penicillin employed by this proceduse was from 1,200,000 to 1,050,000 units over a period of about 10 days. The result was the change of the nasal discharge from purulent to mucous in character as well. as great reduction in quantity even sometimes to complete disappearance, diminished swelling of the mucous.